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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Lanosterol synthase | ||
| Ligand | BDBM50052351 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_148908 (CHEMBL756145) | ||
| IC50 | >100±n/a nM | ||
| Citation |  Brown, GR; Hollinshead, DM; Stokes, ES; Clarke, DS; Eakin, MA; Foubister, AJ; Glossop, SC; Griffiths, D; Johnson, MC; McTaggart, F; Mirrlees, DJ; Smith, GJ; Wood, R Quinuclidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase: optimization from lipid profiles. J Med Chem42:1306-11 (1999) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Lanosterol synthase | |||
| Name: | Lanosterol synthase | ||
| Synonyms: | LSS_RAT | Lss | Osc | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 83302.12 | ||
| Organism: | Rattus norvegicus | ||
| Description: | ChEMBL_12083 | ||
| Residue: | 733 | ||
| Sequence: |
| ||
| BDBM50052351 | |||
| n/a | |||
| Name | BDBM50052351 | ||
| Synonyms: | 3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]octan-3-ol | 3-biphenyl-4-yl-3-hydroxyquinuclidine | CHEMBL279261 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H21NO | ||
| Mol. Mass. | 279.3761 | ||
| SMILES | OC1(CN2CCC1CC2)c1ccc(cc1)-c1ccccc1 |(10.58,-8.89,;10.59,-10.42,;10.59,-11.97,;9.25,-12.74,;7.92,-11.97,;7.92,-10.42,;9.25,-9.65,;8.51,-11,;10,-11.41,;11.92,-9.66,;13.25,-10.43,;14.59,-9.66,;14.59,-8.12,;13.25,-7.35,;11.92,-8.12,;15.92,-7.35,;17.25,-8.12,;18.58,-7.36,;18.58,-5.81,;17.24,-5.04,;15.91,-5.82,)| | ||
| Structure | 
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