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TargetCorticotropin-releasing factor receptor 2
LigandBDBM50075918
Substrate/Competitorn/a
Meas. Tech.ChEBML_51277
Ki 86±n/a nM
Citation Luthin, DR; Rabinovich, AK; Bhumralkar, DR; Youngblood, KL; Bychowski, RA; Dhanoa, DS; May, JM Synthesis and biological activity of oxo-7H-benzo[e]perimidine-4-carboxylic acid derivatives as potent, nonpeptide corticotropin releasing factor (CRF) receptor antagonists. Bioorg Med Chem Lett9:765-70 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Corticotropin-releasing factor receptor 2
Name:Corticotropin-releasing factor receptor 2
Synonyms:CRF-R-2 | CRF-R2 | CRF-RB | CRFR-2 | CRFR2_MOUSE | CRH-R-2 | CRH-R2 | Corticotropin releasing factor receptor 2 | Corticotropin-releasing factor receptor 2 | Corticotropin-releasing hormone receptor 2 | Crf2r | Crhr2
Type:PROTEIN
Mol. Mass.:47628.12
Organism:Mus musculus
Description:ChEMBL_51276
Residue:411
Sequence:
MDAALLLSLLEANCSLALAEELLLDGWGVPPDPEGPYTYCNTTLDQIGTCWPQSAPGALV
ERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIVN
YLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNIAWFLLQLIDHEVHEGN
EVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIII
AWAVGKLYYENEQCWFGKEAGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRASTTS
ETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYC
FFNGEVRAALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
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  Blast E-value cutoff:
BDBM50075918
n/a
NameBDBM50075918
Synonyms:8N-[2-amino-(1R,2R)-cyclohexyl]-15-oxo-(9aS,13aS)-11,12,13,15-tetrahydro-10H-benzo[7,8]quinazolino[5,4-ab]phenazine-8-carboxamide | CHEMBL168162
TypeSmall organic molecule
Emp. Form.C28H30N6O2
Mol. Mass.482.5768
SMILESN[C@@H]1CCCC[C@H]1NC(=O)c1c2N[C@H]3CCCC[C@@H]3N=c2c2c(O)c3ccccc3c3ncnc1c23 |c:21|
Structure
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