| Reaction Details |
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 | Report a problem with these data |
| Target | Complement C1r subcomponent |
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| Ligand | BDBM50075992 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_48023 |
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| IC50 | 1500±n/a nM |
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| Citation |  Plummer, JS; Cai, C; Hays, SJ; Gilmore, JL; Emmerling, MR; Michael, W; Narasimhan, LS; Watson, MD; Wang, K; Nath, R; Evans, LM; Jaen, JC Benzenesulfonamide derivatives of 2-substituted 4H-3,1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease. Bioorg Med Chem Lett9:815-20 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Complement C1r subcomponent |
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| Name: | Complement C1r subcomponent |
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| Synonyms: | C1R | C1R_HUMAN | Complement C1r | Complement C1r subcomponent |
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| Type: | Enzyme |
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| Mol. Mass.: | 80113.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00736 |
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| Residue: | 705 |
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| Sequence: | MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVF
QQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDF
SNEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGY
ELQEDTHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPF
DIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKL
RYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQD
DGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSR
ESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVF
TNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRV
SVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVME
EKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAV
RDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED
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| BDBM50075992 |
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| n/a |
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| Name | BDBM50075992 |
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| Synonyms: | 4-Guanidino-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamide | CHEMBL167523 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15N5O4S |
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| Mol. Mass. | 373.386 |
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| SMILES | [#6]-[#7](-c1nc2ccccc2c(=O)o1)S(=O)(=O)c1ccc(cc1)\[#7]=[#6](/[#7])-[#7] |
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| Structure | 
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