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TargetIntegrase
LigandBDBM50073628
Substrate/Competitorn/a
Meas. Tech.ChEMBL_90575 (CHEMBL701159)
IC50 400±n/a nM
Citation Lin, ZNeamati, NZhao, HKiryu, YTurpin, JAAberham, CStrebel, KKohn, KWitvrouw, MPannecouque, CDebyser, ZDe Clercq, ERice, WGPommier, YBurke, TR Chicoric acid analogues as HIV-1 integrase inhibitors. J Med Chem42:1401-14 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Integrase
Name:Integrase
Synonyms:Human immunodeficiency virus type 1 integrase
Type:PROTEIN
Mol. Mass.:32231.48
Organism:Human immunodeficiency virus 1
Description:ChEMBL_90865
Residue:288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50073628
n/a
NameBDBM50073628
Synonyms:(E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid 2-[(E)-3-(3,4-dihydroxy-phenyl)-acryloyloxy]-ethyl ester | CHEMBL286477
TypeSmall organic molecule
Emp. Form.C20H18O8
Mol. Mass.386.3521
SMILESOc1ccc(\C=C\C(=O)OCCOC(=O)\C=C\c2ccc(O)c(O)c2)cc1O
Structure
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