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TargetInterstitial collagenase
LigandBDBM50076357
Substrate/Competitorn/a
Meas. Tech.ChEMBL_106319 (CHEMBL714731)
Ki 17000±n/a nM
Citation Jacobsen, EJMitchell, MAHendges, SKBelonga, KLSkaletzky, LLStelzer, LSLindberg, TJFritzen, ELSchostarez, HJO'Sullivan, TJMaggiora, LLStuchly, CWLaborde, ALKubicek, MFPoorman, RABeck, JMMiller, HRPetzold, GLScott, PSTruesdell, SEWallace, TLWilks, JWFisher, CGoodman, LVKaytes, PS Synthesis of a series of stromelysin-selective thiadiazole urea matrix metalloproteinase inhibitors. J Med Chem42:1525-36 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Interstitial collagenase
Name:Interstitial collagenase
Synonyms:CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:Enzyme
Mol. Mass.:54010.26
Organism:Homo sapiens (Human)
Description: P03956
Residue:469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50076357
n/a
NameBDBM50076357
Synonyms:(S)-3-Phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionic acid methyl ester | CHEMBL39392
TypeSmall organic molecule
Emp. Form.C13H14N4O3S2
Mol. Mass.338.405
SMILESCOC(=O)[C@H](Cc1ccccc1)NC(=O)Nc1nnc(S)s1
Structure
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