Reaction Details |
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Target | Interstitial collagenase |
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Ligand | BDBM50076357 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_106319 (CHEMBL714731) |
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Ki | 17000±n/a nM |
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Citation | Jacobsen, EJ; Mitchell, MA; Hendges, SK; Belonga, KL; Skaletzky, LL; Stelzer, LS; Lindberg, TJ; Fritzen, EL; Schostarez, HJ; O'Sullivan, TJ; Maggiora, LL; Stuchly, CW; Laborde, AL; Kubicek, MF; Poorman, RA; Beck, JM; Miller, HR; Petzold, GL; Scott, PS; Truesdell, SE; Wallace, TL; Wilks, JW; Fisher, C; Goodman, LV; Kaytes, PS Synthesis of a series of stromelysin-selective thiadiazole urea matrix metalloproteinase inhibitors. J Med Chem42:1525-36 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interstitial collagenase |
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Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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BDBM50076357 |
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n/a |
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Name | BDBM50076357 |
Synonyms: | (S)-3-Phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionic acid methyl ester | CHEMBL39392 |
Type | Small organic molecule |
Emp. Form. | C13H14N4O3S2 |
Mol. Mass. | 338.405 |
SMILES | COC(=O)[C@H](Cc1ccccc1)NC(=O)Nc1nnc(S)s1 |
Structure |
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