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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50076615 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_50955 | ||
| Ki | 7.6±n/a nM | ||
| Citation |  Beck, JP; Arvanitis, AG; Curry, MA; Rescinito, JT; Fitzgerald, LW; Gilligan, PJ; Zaczek, R; Trainor, GL Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists. Bioorg Med Chem Lett9:967-72 (1999) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50076615 | |||
| n/a | |||
| Name | BDBM50076615 | ||
| Synonyms: | 9-(2-Bromo-4-isopropyl-phenyl)-6-dipropylamino-2,7-dimethyl-7,9-dihydro-purin-8-one | CHEMBL426044 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H30BrN5O | ||
| Mol. Mass. | 460.411 | ||
| SMILES | CCCN(CCC)c1nc(C)nc2n(-c3ccc(cc3Br)C(C)C)c(=O)n(C)c12 |(2.75,-1.64,;4.09,-2.41,;4.09,-3.95,;5.44,-4.72,;6.77,-3.95,;6.75,-2.41,;8.08,-1.62,;5.44,-6.26,;4.11,-7.03,;4.11,-8.57,;2.78,-9.34,;5.44,-9.34,;6.8,-8.57,;8.27,-9.04,;8.75,-10.5,;7.72,-11.64,;8.2,-13.1,;9.71,-13.42,;10.74,-12.26,;10.25,-10.8,;11.27,-9.64,;10.2,-14.87,;11.71,-15.19,;9.18,-16.03,;9.17,-7.78,;10.71,-7.78,;8.24,-6.54,;8.71,-5.07,;6.79,-7.03,)| | ||
| Structure | 
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