Reaction Details |
| Report a problem with these data |
Target | Corticotropin-releasing factor receptor 1 |
---|
Ligand | BDBM50076764 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_50975 |
---|
Ki | 2.5±n/a nM |
---|
Citation | Cocuzza, AJ; Hobbs, FW; Arnold, CR; Chidester, DR; Yarem, JA; Culp, S; Fitzgerald, L; Gilligan, PJ 4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists. Bioorg Med Chem Lett9:1057-62 (1999) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Corticotropin-releasing factor receptor 1 |
---|
Name: | Corticotropin-releasing factor receptor 1 |
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 |
Type: | Enzyme |
Mol. Mass.: | 50744.31 |
Organism: | Homo sapiens (Human) |
Description: | P34998 |
Residue: | 444 |
Sequence: | MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
|
|
|
BDBM50076764 |
---|
n/a |
---|
Name | BDBM50076764 |
Synonyms: | (2-Bromo-4-methylsulfanyl-phenyl)-ethyl-[4-methyl-6-(2-trifluoromethyl-phenyl)-pyrimidin-2-yl]-amine | CHEMBL274578 |
Type | Small organic molecule |
Emp. Form. | C21H19BrF3N3S |
Mol. Mass. | 482.36 |
SMILES | CCN(c1nc(C)cc(n1)-c1ccccc1C(F)(F)F)c1ccc(SC)cc1Br |
Structure |
|