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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50076898 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_51119 | ||
| Ki | 16±n/a nM | ||
| Citation |  Beck, JP; Curry, MA; Chorvat, RJ; Fitzgerald, LW; Gilligan, PJ; Zaczek, R; Trainor, GL Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists. Bioorg Med Chem Lett9:1185-8 (1999) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50076898 | |||
| n/a | |||
| Name | BDBM50076898 | ||
| Synonyms: | 7-(Cyclopropylmethyl-propyl-amino)-5-methyl-3-(2,4,6-trimethyl-phenyl)-3H-thiazolo[4,5-d]pyrimidin-2-one | CHEMBL18590 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H28N4OS | ||
| Mol. Mass. | 396.549 | ||
| SMILES | CCCN(CC1CC1)c1nc(C)nc2n(-c3c(C)cc(C)cc3C)c(=O)sc12 |(16.68,-10.17,;15.34,-10.93,;15.36,-12.48,;14.02,-13.25,;12.68,-12.49,;12.68,-10.96,;13.43,-9.63,;11.91,-9.63,;14.02,-14.78,;12.7,-15.57,;12.7,-17.11,;11.37,-17.87,;14.02,-17.87,;15.36,-17.1,;16.82,-17.55,;17.32,-19.02,;18.81,-19.32,;19.81,-18.16,;19.3,-20.77,;18.27,-21.91,;18.76,-23.38,;16.76,-21.62,;16.28,-20.16,;14.78,-19.84,;17.73,-16.31,;19.27,-16.3,;16.82,-15.07,;15.36,-15.55,)| | ||
| Structure | 
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