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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50076899 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_51119 (CHEMBL665732) | ||
| Ki | 6.6±n/a nM | ||
| Citation |  Beck, JP; Curry, MA; Chorvat, RJ; Fitzgerald, LW; Gilligan, PJ; Zaczek, R; Trainor, GL Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists. Bioorg Med Chem Lett9:1185-8 (1999) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50076899 | |||
| n/a | |||
| Name | BDBM50076899 | ||
| Synonyms: | 7-[Bis-(2-methoxy-ethyl)-amino]-3-(2-bromo-4-isopropyl-phenyl)-5-methyl-3H-thiazolo[4,5-d]pyrimidine-2-thione | CHEMBL559127 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H27BrN4O2S2 | ||
| Mol. Mass. | 511.499 | ||
| SMILES | COCCN(CCOC)c1nc(C)nc2n(-c3ccc(cc3Br)C(C)C)c(=S)sc12 |(18.56,-10.19,;17.24,-9.42,;15.9,-10.19,;15.9,-11.74,;14.58,-12.51,;13.24,-11.74,;13.24,-10.22,;11.9,-9.45,;10.57,-10.22,;14.59,-14.04,;13.26,-14.83,;13.26,-16.37,;11.93,-17.14,;14.59,-17.14,;15.93,-16.35,;17.4,-16.83,;17.88,-18.27,;16.85,-19.43,;17.33,-20.89,;18.85,-21.19,;19.88,-20.04,;19.38,-18.59,;20.47,-17.49,;19.33,-22.66,;18.31,-23.81,;20.84,-22.97,;18.31,-15.57,;19.84,-15.57,;17.38,-14.33,;15.92,-14.81,)| | ||
| Structure | 
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