| Reaction Details |
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 | Report a problem with these data |
| Target | Prothrombin |
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| Ligand | BDBM50077054 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_208529 |
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| Ki | 1000±n/a nM |
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| Citation |  Ambler, J; Brown, L; Cockcroft, XL; Grütter, M; Hayler, J; Janus, D; Jones, D; Kane, P; Menear, K; Priestle, J; Smith, G; Talbot, M; Walker, CV; Wathey, B Optimisation of the P2 pharmacophore in a series of thrombin inhibitors: ion-dipole interactions with lysine 60G. Bioorg Med Chem Lett9:1317-22 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Prothrombin |
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| Name: | Prothrombin |
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| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
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| Type: | Protein |
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| Mol. Mass.: | 70029.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00734 |
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| Residue: | 622 |
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| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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| BDBM50077054 |
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| n/a |
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| Name | BDBM50077054 |
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| Synonyms: | 3,3-Dimethyl-1,2,3,4-tetrahydro-quinoline-8-sulfonic acid ((S)-1-benzothiazol-2-ylmethyl-2-{4-[2-(3,3-dimethyl-ureido)-ethyl]-piperidin-1-yl}-2-oxo-ethyl)-amide | CHEMBL282065 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H42N6O4S2 |
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| Mol. Mass. | 626.833 |
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| SMILES | CN(C)C(=O)NCCC1CCN(CC1)C(=O)[C@H](Cc1nc2ccccc2s1)NS(=O)(=O)c1cccc2CC(C)(C)CNc12 |
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| Structure | 
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