| Reaction Details |
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 | Report a problem with these data |
| Target | Serotonin (5-HT) receptor |
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| Ligand | BDBM50077658 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_202317 |
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| Ki | 2.7±n/a nM |
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| Citation |  Ahn KH; Lee SJ; Lee CH; Hong CY; Park TK N-substituted-3-arylpyrrolidines: potent and selective ligands at serotonin 1A receptor. Bioorg Med Chem Lett 9:1379-84 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Serotonin (5-HT) receptor |
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| Name: | Serotonin 1 (5-HT1) receptor |
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| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A | 5-hydroxytryptamine receptor 1A (5HT1A) | G-21 | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46445.29 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Binding assays were performed using rat hippocampal membranes. |
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| Residue: | 422 |
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| Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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| BDBM50077658 |
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| n/a |
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| Name | BDBM50077658 |
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| Synonyms: | 1,1-Dioxo-2-[4-(3-phenyl-pyrrolidin-1-yl)-butyl]-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one | CHEMBL28831 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N2O3S |
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| Mol. Mass. | 384.492 |
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| SMILES | O=C1N(CCCCN2CCC(C2)c2ccccc2)S(=O)(=O)c2ccccc12 |
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| Structure | 
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