| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50077698 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_195757 |
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| IC50 | 10±n/a nM |
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| Citation |  Güller, R; Binggeli, A; Breu, V; Bur, D; Fischli, W; Hirth, G; Jenny, C; Kansy, M; Montavon, F; Müller, M; Oefner, C; Stadler, H; Vieira, E; Wilhelm, M; Wostl, W; Märki, HP Piperidine-renin inhibitors compounds with improved physicochemical properties. Bioorg Med Chem Lett9:1403-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50077698 |
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| n/a |
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| Name | BDBM50077698 |
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| Synonyms: | 5-[(3R,4R)-3-(1,4-Dimethoxy-naphthalen-2-ylmethoxy)-piperidin-4-yl]-2-[3-(2-methoxy-benzyloxy)-propoxy]-pyrimidine | CHEMBL31404 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H39N3O6 |
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| Mol. Mass. | 573.6793 |
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| SMILES | COc1ccccc1COCCCOc1ncc(cn1)[C@H]1CCNC[C@@H]1OCc1cc(OC)c2ccccc2c1OC |
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| Structure | 
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