| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydrofolate reductase |
|---|
| Ligand | BDBM50077797 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_53605 (CHEMBL664356) |
|---|
| Ki | 46±n/a nM |
|---|
| Citation |  Zuccotto, F; Brun, R; Gonzalez Pacanowska, D; Ruiz Perez, LM; Gilbert, IH The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase. Bioorg Med Chem Lett9:1463-8 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydrofolate reductase |
|---|
| Name: | Dihydrofolate reductase |
|---|
| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 21453.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human DHFR. |
|---|
| Residue: | 187 |
|---|
| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
|---|
| BDBM50077797 |
|---|
| n/a |
|---|
| Name | BDBM50077797 |
|---|
| Synonyms: | 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-(4-ethoxycarbonyl-butyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester | CHEMBL35552 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H40N8O7 |
|---|
| Mol. Mass. | 624.688 |
|---|
| SMILES | CCOC(=O)CCCCN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCC(=O)OCC)C(=O)OCC |
|---|
| Structure | 
|
|---|
Search and Browse
