| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50077794 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_53605 (CHEMBL664356) |
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| Ki | 14±n/a nM |
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| Citation |  Zuccotto, F; Brun, R; Gonzalez Pacanowska, D; Ruiz Perez, LM; Gilbert, IH The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase. Bioorg Med Chem Lett9:1463-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50077794 |
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| n/a |
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| Name | BDBM50077794 |
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| Synonyms: | 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-(3-ethoxycarbonyl-propyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester | CHEMBL285474 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H38N8O7 |
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| Mol. Mass. | 610.6614 |
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| SMILES | CCOC(=O)CCCN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCC(=O)OCC)C(=O)OCC |
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| Structure | 
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