| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50077798 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_53605 (CHEMBL664356) |
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| Ki | 0.107000±n/a nM |
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| Citation |  Zuccotto, F; Brun, R; Gonzalez Pacanowska, D; Ruiz Perez, LM; Gilbert, IH The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase. Bioorg Med Chem Lett9:1463-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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|
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| BDBM50077798 |
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| n/a |
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| Name | BDBM50077798 |
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| Synonyms: | 2-{4-[(3-Carboxy-propyl)-(2,4-diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | CHEMBL35364 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26N8O7 |
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| Mol. Mass. | 526.5019 |
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| SMILES | Nc1nc(N)c2nc(CN(CCCC(O)=O)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cnc2n1 |
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| Structure | 
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