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TargetThymidylate Synthase (TS)
LigandBDBM50077839
Substrate/Competitorn/a
Meas. Tech.ChEMBL_209135
Ki 26000±n/a nM
Citation Costi PMRinaldi MTondi DPecorari PBarlocco DGhelli SStroud RMSanti DVStout TJMusiu CMarangiu EMPani ACongiu DLoi GALa Colla P Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition. J Med Chem 42:2112-24 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thymidylate Synthase (TS)
Name:Thymidylate Synthase (TS)
Synonyms:TS | TSase
Type:Enzyme
Mol. Mass.:30475.81
Organism:Escherichia coli
Description:n/a
Residue:264
Sequence:
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL
WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK
NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS
YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF
DYRFEDFEIEGYDPHPGIKAPVAI
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  Blast E-value cutoff:
BDBM50077839
n/a
NameBDBM50077839
Synonyms:3-Hydroxy-3-(2-hydroxy-3-isopropyl-6-methyl-phenyl)-3H-benzo[de]isochromen-1-one | CHEMBL69792
TypeSmall organic molecule
Emp. Form.C22H20O4
Mol. Mass.348.3918
SMILESCC(C)c1ccc(C)c(c1O)C1(O)OC(=O)c2cccc3cccc1c23
Structure
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