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TargetThymidylate synthase
LigandBDBM18763
Substrate/Competitorn/a
Meas. Tech.ChEMBL_209135 (CHEMBL814653)
Ki 700±n/a nM
Citation Costi, PMRinaldi, MTondi, DPecorari, PBarlocco, DGhelli, SStroud, RMSanti, DVStout, TJMusiu, CMarangiu, EMPani, ACongiu, DLoi, GALa Colla, P Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition. J Med Chem42:2112-24 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thymidylate synthase
Name:Thymidylate synthase
Synonyms:TS | TSase | TYSY_ECOLI | Thymidylate Synthase (TS) | thyA
Type:Enzyme
Mol. Mass.:30475.81
Organism:Escherichia coli
Description:n/a
Residue:264
Sequence:
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL
WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK
NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS
YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF
DYRFEDFEIEGYDPHPGIKAPVAI
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  Blast E-value cutoff:
BDBM18763
n/a
NameBDBM18763
Synonyms:1,8-naphthalein derivative, 10 | 4,4-bis(3-chloro-4-hydroxyphenyl)-3-oxatricyclo[7.3.1.0^{5,13}]trideca-1(12),5,7,9(13),10-pentaen-2-one | A15 | A156 | Alpha 156 | CHEMBL67116
TypeSmall organic molecule
Emp. Form.C24H14Cl2O4
Mol. Mass.437.272
SMILESOc1ccc(cc1Cl)C1(OC(=O)c2cccc3cccc1c23)c1ccc(O)c(Cl)c1
Structure
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