Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 2A

Ligand

BDBM50010594

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2584 (CHEMBL617605)

IC50

12±n/a nM

Citation

Liao, Y; Venhuis, BJ; Rodenhuis, N; Timmerman, W; Wikström, H; Meier, E; Bartoszyk, GD; Böttcher, H; Seyfried, CA; Sundell, S New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation. J Med Chem42:2235-44 (1999) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 2A

Name:

5-hydroxytryptamine receptor 2A

Synonyms:

5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

52852.05

Organism:

Rattus norvegicus (rat)

Description:

Rat cortex membranes 5-HT2A receptors.

Residue:

471

Sequence:

MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV

BDBM50010594

n/a

Name

BDBM50010594

Synonyms:

2-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine | 2-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(isoclozapine) | CHEMBL415300 | ISOCLOZAPINE

Type

Small organic molecule

Emp. Form.

C18H19ClN4

Mol. Mass.

326.823

SMILES

CN1CCN(CC1)C1=Nc2ccccc2Nc2ccc(Cl)cc12 |t:8|

Structure