Ki Summary

Reaction Details

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Target

Xaa-Pro aminopeptidase 2

Ligand

BDBM50078391

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_35520 (CHEMBL644753)

IC50

11000±n/a nM

Citation

Maggiora, LL; Orawski, AT; Simmons, WH Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem42:2394-402 (1999) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Xaa-Pro aminopeptidase 2

Name:

Xaa-Pro aminopeptidase 2

Synonyms:

Membrane-bound aminopeptidase P (APP2) | XPNPEP2 | XPP2_HUMAN | Xaa-Pro aminopeptidase 2

Type:

Enzyme

Mol. Mass.:

75618.88

Organism:

Homo sapiens (Human)

Description:

O43895

Residue:

674

Sequence:

MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQ
MQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQ
AERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQL
VSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLS
ALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCV
QIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSK
EQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETIS
ASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYT
RVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQ
SNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNL
IDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWAS
VLVVSTLAILGWSV

BDBM50078391

n/a

Name

BDBM50078391

Synonyms:

(S)-1-[(R)-3-((2S,3R)-3-Amino-2-hydroxy-4-phenyl-butyryl)-thiazolidine-4-carbonyl]-pyrrolidine-2-carboxylic acid ((S)-1-carbamoyl-ethyl)-amide | CHEMBL79092

Type

Small organic molecule

Emp. Form.

C22H31N5O5S

Mol. Mass.

477.577

SMILES

C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSCN1C(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(N)=O

Structure