| Reaction Details |
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 | Report a problem with these data |
| Target | Xaa-Pro aminopeptidase 2 |
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| Ligand | BDBM50078392 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_35520 (CHEMBL644753) |
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| IC50 | 31000±n/a nM |
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| Citation |  Maggiora, LL; Orawski, AT; Simmons, WH Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem42:2394-402 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Xaa-Pro aminopeptidase 2 |
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| Name: | Xaa-Pro aminopeptidase 2 |
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| Synonyms: | Membrane-bound aminopeptidase P (APP2) | XPNPEP2 | XPP2_HUMAN | Xaa-Pro aminopeptidase 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 75618.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43895 |
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| Residue: | 674 |
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| Sequence: | MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQ
MQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQ
AERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQL
VSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLS
ALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCV
QIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSK
EQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETIS
ASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYT
RVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQ
SNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNL
IDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWAS
VLVVSTLAILGWSV
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| BDBM50078392 |
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| n/a |
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| Name | BDBM50078392 |
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| Synonyms: | (S)-1-((2R,3R)-3-Amino-2-hydroxy-5-methyl-hexanoyl)-pyrrolidine-2-carboxylic acid ((S)-1-carbamoyl-ethyl)-amide | CHEMBL81423 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H28N4O4 |
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| Mol. Mass. | 328.4072 |
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| SMILES | CC(C)C[C@@H](N)[C@@H](O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O |
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| Structure | 
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