| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50039542 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_162028 (CHEMBL873419) |
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| Ki | 3.1±n/a nM |
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| Citation |  Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH Structure-activity relationships for a class of inhibitors of purine nucleoside phosphorylase. J Med Chem42:2422-31 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | NP | PNP | PNPH_BOVIN | Purine Nucleoside Phosphorylase (PNP) | Purine nucleoside phosphorylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 32035.18 |
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| Organism: | Bos taurus (bovine) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPEST
VPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGL
NPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQ
MGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
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| BDBM50039542 |
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| n/a |
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| Name | BDBM50039542 |
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| Synonyms: | 2-Amino-7-pyridin-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one | 2-amino-7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | 2-amino-7-(pyridin-3-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one | CHEMBL311300 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H11N5O |
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| Mol. Mass. | 241.2486 |
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| SMILES | Nc1nc2c(Cc3cccnc3)c[nH]c2c(=O)[nH]1 |
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| Structure | 
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