| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease 1 |
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| Ligand | BDBM50079211 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_212878 (CHEMBL824706) |
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| Ki | 52±n/a nM |
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| Citation |  Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2. J Med Chem42:2760-73 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease 1 |
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| Name: | Serine protease 1 |
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| Synonyms: | Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 26557.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07477 |
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| Residue: | 247 |
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| Sequence: | MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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| BDBM50079211 |
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| n/a |
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| Name | BDBM50079211 |
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| Synonyms: | CHEMBL327404 | {3-(3-Carbamimidoyl-phenyl)-5-[5-(2-sulfamoyl-phenyl)-pyridin-2-ylcarbamoyl]-4,5-dihydro-isoxazol-5-yl}-acetic acid methyl ester; TFA |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24N6O6S |
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| Mol. Mass. | 536.56 |
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| SMILES | COC(=O)CC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O |c:7| |
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| Structure | 
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