| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1 |
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| Ligand | BDBM7263 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_50351 (CHEMBL662511) |
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| IC50 | 24±n/a nM |
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| Citation |  Schultz, C; Link, A; Leost, M; Zaharevitz, DW; Gussio, R; Sausville, EA; Meijer, L; Kunick, C Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. J Med Chem42:2909-19 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 1 |
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| Name: | Cyclin-dependent kinase 1 |
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| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 34101.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06493 |
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| Residue: | 297 |
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| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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| BDBM7263 |
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| n/a |
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| Name | BDBM7263 |
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| Synonyms: | 9-cyanopaullone | 9-oxo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaene-14-carbonitrile | CHEMBL299756 | NSC 704626 | Paullone Analog 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11N3O |
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| Mol. Mass. | 273.2887 |
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| SMILES | O=C1Cc2c([nH]c3ccc(cc23)C#N)-c2ccccc2N1 |
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| Structure | 
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