| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin receptor type B |
|---|
| Ligand | BDBM50079431 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_63846 (CHEMBL673230) |
|---|
| Ki | 60±n/a nM |
|---|
| Citation |  Amberg, W; Hergenröder, S; Hillen, H; Jansen, R; Kettschau, G; Kling, A; Klinge, D; Raschack, M; Riechers, H; Unger, L Discovery and synthesis of (S)-3-[2-(3,4-dimethoxyphenyl)ethoxy]-2- (4,6-dimethylpyrimidin-2-yloxy)-3,3-diphenylpropionic acid (LU 302872), a novel orally active mixed ET(A)/ET(B) receptor antagonist. J Med Chem42:3026-32 (1999) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin receptor type B |
|---|
| Name: | Endothelin receptor type B |
|---|
| Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 49664.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
|---|
| Residue: | 442 |
|---|
| Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
|
|
|
|---|
| BDBM50079431 |
|---|
| n/a |
|---|
| Name | BDBM50079431 |
|---|
| Synonyms: | 3-(3,4-Dimethoxy-phenoxy)-2-(4,6-dimethyl-pyrimidin-2-yloxy)-3,3-diphenyl-propionic acid | CHEMBL320224 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H28N2O6 |
|---|
| Mol. Mass. | 500.5424 |
|---|
| SMILES | COc1ccc(OC(C(Oc2nc(C)cc(C)n2)C(O)=O)(c2ccccc2)c2ccccc2)cc1OC |
|---|
| Structure | 
|
|---|
Search and Browse
