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TargetEndothelin receptor type B
LigandBDBM50079434
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63846 (CHEMBL673230)
Ki 195±n/a nM
Citation Amberg, WHergenröder, SHillen, HJansen, RKettschau, GKling, AKlinge, DRaschack, MRiechers, HUnger, L Discovery and synthesis of (S)-3-[2-(3,4-dimethoxyphenyl)ethoxy]-2- (4,6-dimethylpyrimidin-2-yloxy)-3,3-diphenylpropionic acid (LU 302872), a novel orally active mixed ET(A)/ET(B) receptor antagonist. J Med Chem42:3026-32 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Endothelin receptor type B
Name:Endothelin receptor type B
Synonyms:EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B
Type:Enzyme Catalytic Domain
Mol. Mass.:49664.00
Organism:Homo sapiens (Human)
Description:ENDOTHELIN B EDNRB HUMAN::P24530
Residue:442
Sequence:
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50079434
n/a
NameBDBM50079434
Synonyms:2-(4,6-Dimethyl-pyrimidin-2-yloxy)-3,3-bis-(4-ethyl-phenyl)-3-[2-(4-methoxy-phenyl)-ethoxy]-propionic acid | CHEMBL317716
TypeSmall organic molecule
Emp. Form.C34H38N2O5
Mol. Mass.554.6759
SMILESCCc1ccc(cc1)C(OCCc1ccc(OC)cc1)(C(Oc1nc(C)cc(C)n1)C(O)=O)c1ccc(CC)cc1
Structure
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