| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50079434 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_65646 (CHEMBL678558) |
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| Ki | 250±n/a nM |
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| Citation |  Amberg, W; Hergenröder, S; Hillen, H; Jansen, R; Kettschau, G; Kling, A; Klinge, D; Raschack, M; Riechers, H; Unger, L Discovery and synthesis of (S)-3-[2-(3,4-dimethoxyphenyl)ethoxy]-2- (4,6-dimethylpyrimidin-2-yloxy)-3,3-diphenylpropionic acid (LU 302872), a novel orally active mixed ET(A)/ET(B) receptor antagonist. J Med Chem42:3026-32 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50079434 |
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| n/a |
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| Name | BDBM50079434 |
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| Synonyms: | 2-(4,6-Dimethyl-pyrimidin-2-yloxy)-3,3-bis-(4-ethyl-phenyl)-3-[2-(4-methoxy-phenyl)-ethoxy]-propionic acid | CHEMBL317716 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H38N2O5 |
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| Mol. Mass. | 554.6759 |
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| SMILES | CCc1ccc(cc1)C(OCCc1ccc(OC)cc1)(C(Oc1nc(C)cc(C)n1)C(O)=O)c1ccc(CC)cc1 |
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| Structure | 
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