Reaction Details |
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Target | Cathepsin K |
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Ligand | BDBM50079596 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_48317 |
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Ki | 10±n/a nM |
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Citation | Duffy, KJ; Ridgers, LH; DesJarlais, RL; Tomaszek, TA; Bossard, MJ; Thompson, SK; Keenan, RM; Veber, DF Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K. Bioorg Med Chem Lett9:1907-10 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin K |
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Name: | Cathepsin K |
Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
Type: | Enzyme |
Mol. Mass.: | 36975.68 |
Organism: | Homo sapiens (Human) |
Description: | P43235 |
Residue: | 329 |
Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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BDBM50079596 |
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n/a |
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Name | BDBM50079596 |
Synonyms: | ((S)-1-{N'-[2-((S)-1-Benzyloxycarbonylamino-3-methyl-butyl)-thiazole-4-carbonyl]-hydrazinocarbonyl}-3-methyl-butyl)-carbamic acid benzyl ester | (1-{N'-[2-(1-Benzyloxycarbonylamino-3-methyl-butyl)-thiazole-4-carbonyl]-hydrazinocarbonyl}-3-methyl-butyl)-carbamic acid benzyl ester | CHEMBL57836 | N-[2-[1-(N-BENZYLOXYCARBONYLAMINO)-3-METHYLBUTYL]THIAZOL-4-YLCARBONYL]-N'-(BENZYLOXYCARBONYL-L-LEUCINYL)HYDRAZIDE |
Type | Small organic molecule |
Emp. Form. | C31H39N5O6S |
Mol. Mass. | 609.736 |
SMILES | CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NNC(=O)c1csc(n1)[C@H](CC(C)C)NC(=O)OCc1ccccc1 |
Structure |
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