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TargetGag-Pol polyprotein [489-587]
LigandBDBM50078088
Substrate/Competitorn/a
Meas. Tech.ChEMBL_79953 (CHEMBL687724)
pH6.2±n/a
IC50 1±n/a nM
Commentsextracted
Citation Ellsworth, ELDomagala, JPrasad, JVHagen, SFerguson, DHoller, THupe, DGraham, NNouhan, CTummino, PJZeikus, GLunney, EA 4-hydroxy-5,6-dihydro-2H-pyran-2-ones.3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1' and S2' of the HIV-1 protease enzyme. Bioorg Med Chem Lett9:2019-24 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Gag-Pol polyprotein [489-587]
Name:Gag-Pol polyprotein [489-587]
Synonyms:Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10781.16
Organism:Human immunodeficiency virus type 1
Description:P04585[489-587]
Residue:99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50078088
n/a
NameBDBM50078088
Synonyms:(S)-3-(2-tert-Butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-[2-(4-hydroxy-phenyl)-ethyl]-6-isopropyl-5,6-dihydro-pyran-2-one | CHEMBL37037
TypeSmall organic molecule
Emp. Form.C28H36O5S
Mol. Mass.484.647
SMILESCC(C)[C@]1(CCc2ccc(O)cc2)CC(=O)C(Sc2cc(C)c(CO)cc2C(C)(C)C)C(=O)O1
Structure
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