| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Peptidyl-prolyl cis-trans isomerase FKBP1A |
|---|
| Ligand | BDBM50079765 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_66268 |
|---|
| EC50 | 5.3±n/a nM |
|---|
| Citation |  Goulet, MT; Sinclair, PJ; Wong, F; Staruch, MJ; Dumont, FJ; Cryan, JG; Wiederrecht, GJ; Wyvratt, MJ; Parsons, WH C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study. Bioorg Med Chem Lett9:2085-8 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Peptidyl-prolyl cis-trans isomerase FKBP1A |
|---|
| Name: | Peptidyl-prolyl cis-trans isomerase FKBP1A |
|---|
| Synonyms: | 12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B |
|---|
| Type: | Isomerase |
|---|
| Mol. Mass.: | 11953.09 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P62942 |
|---|
| Residue: | 108 |
|---|
| Sequence: | MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
|
|
|
|---|
| BDBM50079765 |
|---|
| n/a |
|---|
| Name | BDBM50079765 |
|---|
| Synonyms: | C32-O-Phenalkyl ether derivative of Ascomycin | C32-O-cinnamyl ether analogue of L-683590 | CHEMBL293155 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C50H75NO12 |
|---|
| Mol. Mass. | 882.13 |
|---|
| SMILES | CC[C@@H]1\C=C(C)\C[C@H](C)C[C@H](OC)[C@H]2O[C@](O)([C@H](C)C[C@@H]2OC)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@@H]([C@H](C)[C@@H](O)CC1=O)C(\C)=C\[C@@H]1CC[C@@H](OCc2ccccc2)[C@@H](C1)OC |c:3| |
|---|
| Structure | 
|
|---|
Search and Browse
