| Reaction Details |
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 | Report a problem with these data |
| Target | Protein phosphatase 3 catalytic subunit alpha |
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| Ligand | BDBM50079781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_42586 |
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| IC50 | 8.7±n/a nM |
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| Citation |  Armstrong, HM; Wong, F; Holmes, MA; Sinclair, PJ; Goulet, MT; Dumont, FJ; Staruch, MJ; Koprak, S; Peterson, LB; Rosa, R; Wilusz, MB; Wiederrecht, GJ; Cryan, JG; Wyvratt, MJ; Parsons, WH Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity. Bioorg Med Chem Lett9:2089-94 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein phosphatase 3 catalytic subunit alpha |
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| Name: | Protein phosphatase 3 catalytic subunit alpha |
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| Synonyms: | CALNA | CNA | PP2BA_HUMAN | PPP3CA | Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | calcineurin |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58681.14 |
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| Organism: | Homo sapiens (Human) |
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| Description: | calcineurin 0 HUMAN::Q08209 |
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| Residue: | 521 |
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| Sequence: | MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRIN
ERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ
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| BDBM50079781 |
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| n/a |
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| Name | BDBM50079781 |
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| Synonyms: | 12-(2-{4-[2-(3,4-Difluoro-phenyl)-2-hydroxy-ethoxy]-3-methoxy-cyclohexyl}-1-methyl-vinyl)-17-ethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0*4,9*]octacos-18-ene-2,3,10,16-tetraone | CHEMBL431368 |
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| Type | Small organic molecule |
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| Emp. Form. | C51H75F2NO13 |
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| Mol. Mass. | 948.1369 |
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| SMILES | CC[C@@H]1\C=C(C)\C[C@H](C)C[C@H](OC)[C@H]2O[C@](O)([C@H](C)C[C@@H]2OC)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@@H]([C@H](C)[C@H](O)CC1=O)C(\C)=C\C1CC[C@@H](OC[C@H](O)c2ccc(F)c(F)c2)[C@@H](C1)OC |c:3| |
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| Structure | 
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