| Reaction Details |
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 | Report a problem with these data |
| Target | Folylpolyglutamate synthase, mitochondrial |
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| Ligand | BDBM50080449 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_68520 (CHEMBL676944) |
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| Ki | 110000±n/a nM |
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| Citation |  Rosowsky, A; Forsch, RA; Null, A; Moran, RG 5-deazafolate analogues with a rotationally restricted glutamate or ornithine side chain: synthesis and binding interaction with folylpolyglutamate synthetase. J Med Chem42:3510-9 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Folylpolyglutamate synthase, mitochondrial |
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| Name: | Folylpolyglutamate synthase, mitochondrial |
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| Synonyms: | FOLC_HUMAN | FPGS | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64621.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_68676 |
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| Residue: | 587 |
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| Sequence: | MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
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| BDBM50080449 |
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| n/a |
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| Name | BDBM50080449 |
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| Synonyms: | (S)-5-Amino-2-{5-[(2-amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-1-oxo-1,3-dihydro-isoindol-2-yl}-pentanoic acid | CHEMBL117462 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23N7O4 |
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| Mol. Mass. | 437.4518 |
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| SMILES | NCCC[C@H](N1Cc2cc(NCc3cnc4nc(N)[nH]c(=O)c4c3)ccc2C1=O)C(O)=O |
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| Structure | 
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