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TargetEndothelin receptor type B
LigandBDBM50080594
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63675 (CHEMBL670478)
IC50 4±n/a nM
Citation von Geldern, TWTasker, ASSorensen, BKWinn, MSzczepankiewicz, BGDixon, DBChiou, WJWang, LWessale, JLAdler, AMarsh, KCNguyen, BOpgenorth, TJ Pyrrolidine-3-carboxylic acids as endothelin antagonists. 4. Side chain conformational restriction leads to ET(B) selectivity. J Med Chem42:3668-78 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Endothelin receptor type B
Name:Endothelin receptor type B
Synonyms:EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B
Type:Enzyme Catalytic Domain
Mol. Mass.:49664.00
Organism:Homo sapiens (Human)
Description:ENDOTHELIN B EDNRB HUMAN::P24530
Residue:442
Sequence:
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50080594
n/a
NameBDBM50080594
Synonyms:(2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2-ethyl-6-methyl-phenylcarbamoyl)-methyl]-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid | CHEMBL421073
TypeSmall organic molecule
Emp. Form.C30H32N2O6
Mol. Mass.516.5849
SMILESCCc1cccc(C)c1NC(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1
Structure
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