Reaction Details |
| Report a problem with these data |
Target | Endothelin receptor type B |
---|
Ligand | BDBM50080623 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_63674 (CHEMBL670477) |
---|
IC50 | 0.71±n/a nM |
---|
Citation | Liu, G; Kozmina, NS; Winn, M; von Geldern, TW; Chiou, WJ; Dixon, DB; Nguyen, B; Marsh, KC; Opgenorth, TJ Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ET(B) antagonists containing a diphenylmethylamine acetamide side chain. J Med Chem42:3679-89 (1999) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Endothelin receptor type B |
---|
Name: | Endothelin receptor type B |
Synonyms: | EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 49664.00 |
Organism: | Homo sapiens (Human) |
Description: | ENDOTHELIN B EDNRB HUMAN::P24530 |
Residue: | 442 |
Sequence: | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNA
SLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
|
|
|
BDBM50080623 |
---|
n/a |
---|
Name | BDBM50080623 |
Synonyms: | (2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,2-dimethyl-1-phenyl-propylcarbamoyl)-methyl]-2-[4-(2-isopropoxy-ethoxy)-phenyl]-pyrrolidine-3-carboxylic acid; TFA | CHEMBL332289 |
Type | Small organic molecule |
Emp. Form. | C36H44N2O7 |
Mol. Mass. | 616.7438 |
SMILES | CC(C)OCCOc1ccc(cc1)[C@H]1[C@@H]([C@H](CN1CC(=O)NC(c1ccccc1)C(C)(C)C)c1ccc2OCOc2c1)C(O)=O |
Structure |
|