Ki Summary

Reaction Details

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Target

Scytalone dehydratase

Ligand

BDBM50080936

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_199521

2.30±n/a nM

Citation

Jennings, LD; Wawrzak, Z; Amorose, D; Schwartz, RS; Jordan, DB A new potent inhibitor of fungal melanin biosynthesis identified through combinatorial chemistry. Bioorg Med Chem Lett9:2509-14 (1999) [PubMed]

More Info.:

Get all data from this article, Assay Method

Scytalone dehydratase

Name:

Scytalone dehydratase

Synonyms:

SCYD_MAGO7 | SDH1 | Scytalone dehydratase

Type:

PROTEIN

Mol. Mass.:

20248.63

Organism:

Magnaporthe grisea

Description:

ChEMBL_199536

Residue:

172

Sequence:

MGSQVQKSDEITFSDYLGLMTCVYEWADSYDSKDWDRLRKVIAPTLRIDYRSFLDKLWEA
MPAEEFVGMVSSKQVLGDPTLRTQHFIGGTRWEKVSEDEVIGYHQLRVPHQRYKDTTMKE
VTMKGHAHSANLHWYKKIDGVWKFAGLKPDIRWGEFDFDRIFEDGRETFGDK

BDBM50080936

n/a

Name

BDBM50080936

Synonyms:

3-Chloro-3-methyl-1-trifluoromethyl-cyclobutanecarboxylic acid [(R)-1-(4-bromo-phenyl)-ethyl]-amide | CHEMBL432940

Type

Small organic molecule

Emp. Form.

C15H16BrClF3NO

Mol. Mass.

398.646

SMILES

C[C@@H](NC(=O)C1(CC(C)(Cl)C1)C(F)(F)F)c1ccc(Br)cc1 |wD:1.0,(6.11,-1.45,;6.11,-2.99,;4.79,-3.76,;3.47,-2.99,;3.47,-1.45,;1.92,-2.99,;.84,-1.9,;-.25,-2.98,;-1.03,-1.65,;-1.34,-4.05,;.83,-4.07,;2.32,-4.47,;2.71,-5.97,;1.28,-5.9,;3.92,-5.2,;7.45,-3.76,;7.45,-5.3,;8.79,-6.07,;10.12,-5.3,;11.45,-6.07,;10.12,-3.76,;8.79,-2.99,)|

Structure