| Reaction Details |
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 | Report a problem with these data |
| Target | rRNA adenine N-6-methyltransferase |
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| Ligand | BDBM50081275 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_67531 (CHEMBL679968) |
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| Ki | 10000±n/a nM |
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| Citation |  Hajduk, PJ; Dinges, J; Schkeryantz, JM; Janowick, D; Kaminski, M; Tufano, M; Augeri, DJ; Petros, A; Nienaber, V; Zhong, P; Hammond, R; Coen, M; Beutel, B; Katz, L; Fesik, SW Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis. J Med Chem42:3852-9 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| rRNA adenine N-6-methyltransferase |
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| Name: | rRNA adenine N-6-methyltransferase |
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| Synonyms: | ERM_STREE | ErmAM | Macrolide-lincosamide-streptogramin B resistance protein | erm |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28804.82 |
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| Organism: | Streptococcus pneumoniae |
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| Description: | ChEMBL_67532 |
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| Residue: | 245 |
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| Sequence: | MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTTKLAKISKQVTSIELD
SHLFNLSSEKLKLNIRVTLIHQDILQFQFPNKQRYKIVGSIPYHLSTQIIKKVVFESHAS
DIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAECFHPKPKVNSVLIKLTRHTT
DVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHAKVNNLSTITYEQVLSIFNSYLL
FNGRK
|
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|
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| BDBM50081275 |
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| n/a |
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| Name | BDBM50081275 |
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| Synonyms: | 2-{3-[4-Amino-6-(indan-2-ylamino)-[1,3,5]triazin-2-ylamino]-propyl}-3,5-dichloro-phenol | CHEMBL126068 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22Cl2N6O |
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| Mol. Mass. | 445.345 |
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| SMILES | Nc1nc(NCCCc2c(O)cc(Cl)cc2Cl)nc(NC2Cc3ccccc3C2)n1 |
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| Structure | 
|
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