| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50081499 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_69683 |
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| Ki | 2±n/a nM |
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| Citation |  Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Synthesis, SAR and in vivo activity of novel thienopyridine sulfonamide pyrrolidinones as factor Xa inhibitors. Bioorg Med Chem Lett9:2753-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50081499 |
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| n/a |
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| Name | BDBM50081499 |
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| Synonyms: | 4-Hydroxy-3-[(S)-2-oxo-3-(thieno[2,3-c]pyridine-2-sulfonylamino)-pyrrolidin-1-ylmethyl]-benzamidine | CHEMBL92530 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N5O4S2 |
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| Mol. Mass. | 445.515 |
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| SMILES | NC(=N)c1ccc(O)c(CN2CC[C@H](NS(=O)(=O)c3cc4ccncc4s3)C2=O)c1 |
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| Structure | 
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