| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50081806 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_162011 (CHEMBL764862) |
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| IC50 | 37±n/a nM |
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| Citation |  Yokomatsu, T; Hayakawa, Y; Suemune, K; Kihara, T; Soeda, S; Shimeno, H; Shibuya, S Synthesis and biological evaluation of 1,1-difluoro-2-(tetrahydro-3-furanyl)ethylphosphonic acids possessing a N9-purinylmethyl functional group at the ring. a new class of inhibitors for purine nucleoside phosphorylases. Bioorg Med Chem Lett9:2833-6 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 32119.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 289 |
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| Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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| BDBM50081806 |
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| n/a |
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| Name | BDBM50081806 |
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| Synonyms: | CHEMBL94920 | {1,1-Difluoro-2-[(3R,4S)-4-(6-oxo-1,6-dihydro-purin-9-ylmethyl)-tetrahydro-furan-3-yl]-ethyl}-phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C12H15F2N4O5P |
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| Mol. Mass. | 364.2419 |
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| SMILES | OP(O)(=O)C(F)(F)C[C@H]1COC[C@@H]1Cn1cnc2c1nc[nH]c2=O |
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| Structure | 
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