| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine--tRNA ligase, cytoplasmic |
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| Ligand | BDBM50081838 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_211021 |
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| IC50 | 510±n/a nM |
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| Citation |  Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Janson, C; Mensah, LM; O'Hanlon, PJ; Pope, A; Saldanha, A; Qiu, X Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex. Bioorg Med Chem Lett9:2859-62 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine--tRNA ligase, cytoplasmic |
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| Name: | Tyrosine--tRNA ligase, cytoplasmic |
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| Synonyms: | SYYC_HUMAN | Tyrosyl-tRNA synthetase | YARS | YARS1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59145.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_211030 |
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| Residue: | 528 |
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| Sequence: | MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIA
DFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKG
TDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVD
AQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKED
VKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFA
AEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEP
EEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLV
VVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEE
LKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
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| BDBM50081838 |
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| n/a |
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| Name | BDBM50081838 |
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| Synonyms: | CHEMBL318019 | [(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-(2,3,4-trihydroxy-phenyl)-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18N2O7 |
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| Mol. Mass. | 362.334 |
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| SMILES | N[C@@H](Cc1ccc(O)cc1)C(=O)NC(C(O)=O)c1ccc(O)c(O)c1O |
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| Structure | 
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