| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50081915 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_53497 (CHEMBL665621) |
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| Ki | 13±n/a nM |
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| Citation |  Chowdhury, SF; Villamor, VB; Guerrero, RH; Leal, I; Brun, R; Croft, SL; Goodman, JM; Maes, L; Ruiz-Perez, LM; Pacanowska, DG; Gilbert, IH Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase. J Med Chem42:4300-12 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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|
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| BDBM50081915 |
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| n/a |
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| Name | BDBM50081915 |
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| Synonyms: | 5-[3-(Tetrahydro-pyran-2-yloxy)-benzyl]-pyrimidine-2,4-diamine | CHEMBL344592 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H20N4O2 |
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| Mol. Mass. | 300.3556 |
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| SMILES | Nc1ncc(Cc2cccc(OC3CCCCO3)c2)c(N)n1 |
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| Structure | 
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