| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydrofolate reductase |
|---|
| Ligand | BDBM50081906 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_53497 (CHEMBL665621) |
|---|
| Ki | 19±n/a nM |
|---|
| Citation |  Chowdhury, SF; Villamor, VB; Guerrero, RH; Leal, I; Brun, R; Croft, SL; Goodman, JM; Maes, L; Ruiz-Perez, LM; Pacanowska, DG; Gilbert, IH Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase. J Med Chem42:4300-12 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydrofolate reductase |
|---|
| Name: | Dihydrofolate reductase |
|---|
| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 21453.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human DHFR. |
|---|
| Residue: | 187 |
|---|
| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
|
|
|---|
| BDBM50081906 |
|---|
| n/a |
|---|
| Name | BDBM50081906 |
|---|
| Synonyms: | 6-Ethyl-5-(3-heptyloxy-benzyl)-pyrimidine-2,4-diamine | CHEMBL135935 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H30N4O |
|---|
| Mol. Mass. | 342.4784 |
|---|
| SMILES | CCCCCCCOc1cccc(Cc2c(N)nc(N)nc2CC)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
