Reaction Details |
| Report a problem with these data |
Target | Alpha-1A adrenergic receptor |
---|
Ligand | BDBM50082821 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_33740 (CHEMBL647055) |
---|
Ki | 0.2±n/a nM |
---|
Citation | Murali Dhar, TG; Nagarathnam, D; Marzabadi, MR; Lagu, B; Wong, WC; Chiu, G; Tyagarajan, S; Miao, SW; Zhang, F; Sun, W; Tian, D; Shen, Q; Zhang, J; Wetzel, JM; Forray, C; Chang, RS; Broten, TP; Schorn, TW; Chen, TB; O'Malley, S; Ransom, R; Schneck, K; Bendesky, R; Harrell, CM; Vyas, KP Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety. J Med Chem42:4778-93 (1999) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Alpha-1A adrenergic receptor |
---|
Name: | Alpha-1A adrenergic receptor |
Synonyms: | ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C |
Type: | Cell-surface receptors |
Mol. Mass.: | 51511.67 |
Organism: | Homo sapiens (Human) |
Description: | P35348 |
Residue: | 466 |
Sequence: | MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
|
|
|
BDBM50082821 |
---|
n/a |
---|
Name | BDBM50082821 |
Synonyms: | CHEMBL359012 | methyl 4-(3,4-difluorophenyl)-6-methyl-2-oxo-3-[3-spiro[3,4-dihydro-1H-isochromene-1,4'-(hexahydropyridine)]-1-ylpropylcarbamoyl]-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate |
Type | Small organic molecule |
Emp. Form. | C30H34F2N4O5 |
Mol. Mass. | 568.6116 |
SMILES | COC(=O)C1=C(C)NC(=O)N(C1c1ccc(F)c(F)c1)C(=O)NCCCN1CCC2(CC1)OCCc1ccccc21 |c:4| |
Structure |
|