| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1A adrenergic receptor |
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| Ligand | BDBM50082819 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_33740 (CHEMBL647055) |
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| Ki | 0.2±n/a nM |
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| Citation |  Murali Dhar, TG; Nagarathnam, D; Marzabadi, MR; Lagu, B; Wong, WC; Chiu, G; Tyagarajan, S; Miao, SW; Zhang, F; Sun, W; Tian, D; Shen, Q; Zhang, J; Wetzel, JM; Forray, C; Chang, RS; Broten, TP; Schorn, TW; Chen, TB; O'Malley, S; Ransom, R; Schneck, K; Bendesky, R; Harrell, CM; Vyas, KP Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety. J Med Chem42:4778-93 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1A adrenergic receptor |
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| Name: | Alpha-1A adrenergic receptor |
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| Synonyms: | ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C |
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| Type: | Cell-surface receptors |
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| Mol. Mass.: | 51511.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35348 |
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| Residue: | 466 |
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| Sequence: | MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
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| BDBM50082819 |
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| n/a |
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| Name | BDBM50082819 |
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| Synonyms: | 4-(3,4-Difluoro-phenyl)-6-methyl-2-oxo-3-[3-(4-phenyl-piperidin-1-yl)-propylcarbamoyl]-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester | CHEMBL145459 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H32F2N4O4 |
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| Mol. Mass. | 526.5749 |
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| SMILES | COC(=O)C1=C(C)NC(=O)N(C1c1ccc(F)c(F)c1)C(=O)NCCCN1CCC(CC1)c1ccccc1 |c:4| |
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| Structure | 
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