Reaction Details |
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Target | Alpha-1D adrenergic receptor |
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Ligand | BDBM50082827 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_32452 (CHEMBL643400) |
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Ki | 250±n/a nM |
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Citation | Murali Dhar, TG; Nagarathnam, D; Marzabadi, MR; Lagu, B; Wong, WC; Chiu, G; Tyagarajan, S; Miao, SW; Zhang, F; Sun, W; Tian, D; Shen, Q; Zhang, J; Wetzel, JM; Forray, C; Chang, RS; Broten, TP; Schorn, TW; Chen, TB; O'Malley, S; Ransom, R; Schneck, K; Bendesky, R; Harrell, CM; Vyas, KP Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety. J Med Chem42:4778-93 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-1D adrenergic receptor |
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Name: | Alpha-1D adrenergic receptor |
Synonyms: | ADA1D_HUMAN | ADRA1A | ADRA1D | Adrenergic receptor | Adrenergic receptor alpha | Alpha 1D-adrenoceptor | Alpha 1D-adrenoreceptor | Alpha adrenergic receptor (1a and 1d) | Alpha-1D adrenoceptor | Alpha-adrenergic receptor 1a | adrenergic Alpha1D |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 60485.82 |
Organism: | Homo sapiens (Human) |
Description: | adrenergic Alpha1D ADRA1D HUMAN::P25100 |
Residue: | 572 |
Sequence: | MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG
SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS
VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC
TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP
PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS
EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC
WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ
CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM
QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE
AVSLGVPHEVAEGATCQAYELADYSNLRETDI
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BDBM50082827 |
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n/a |
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Name | BDBM50082827 |
Synonyms: | 4-(3,4-Difluoro-phenyl)-6-methyl-2-oxo-3-[3-(4-o-tolyl-4-p-tolyl-piperidin-1-yl)-propylcarbamoyl]-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester | CHEMBL145894 |
Type | Small organic molecule |
Emp. Form. | C36H40F2N4O4 |
Mol. Mass. | 630.724 |
SMILES | COC(=O)C1=C(C)NC(=O)N(C1c1ccc(F)c(F)c1)C(=O)NCCCN1CCC(CC1)(c1ccc(C)cc1)c1ccccc1C |c:4| |
Structure |
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