Reaction Details |
| Report a problem with these data |
Target | Alpha-1D adrenergic receptor |
---|
Ligand | BDBM50082857 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_32453 (CHEMBL643401) |
---|
Ki | 14±n/a nM |
---|
Citation | Lagu, B; Tian, D; Nagarathnam, D; Marzabadi, MR; Wong, WC; Miao, SW; Zhang, F; Sun, W; Chiu, G; Fang, J; Forray, C; Chang, RS; Ransom, RW; Chen, TB; O'Malley, S; Zhang, K; Vyas, KP; Gluchowski, C Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains. J Med Chem42:4794-803 (1999) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Alpha-1D adrenergic receptor |
---|
Name: | Alpha-1D adrenergic receptor |
Synonyms: | ADA1D_HUMAN | ADRA1A | ADRA1D | Adrenergic receptor | Adrenergic receptor alpha | Alpha 1D-adrenoceptor | Alpha 1D-adrenoreceptor | Alpha adrenergic receptor (1a and 1d) | Alpha-1D adrenoceptor | Alpha-adrenergic receptor 1a | adrenergic Alpha1D |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 60485.82 |
Organism: | Homo sapiens (Human) |
Description: | adrenergic Alpha1D ADRA1D HUMAN::P25100 |
Residue: | 572 |
Sequence: | MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG
SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS
VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC
TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP
PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS
EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC
WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ
CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM
QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE
AVSLGVPHEVAEGATCQAYELADYSNLRETDI
|
|
|
BDBM50082857 |
---|
n/a |
---|
Name | BDBM50082857 |
Synonyms: | 4-(3,4-Difluoro-phenyl)-3-{3-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-propylcarbamoyl}-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester | CHEMBL142251 |
Type | Small organic molecule |
Emp. Form. | C29H35F2N5O5 |
Mol. Mass. | 571.6155 |
SMILES | CCOc1ccccc1N1CCN(CCCNC(=O)N2C(C(C(=O)OC)=C(C)NC2=O)c2ccc(F)c(F)c2)CC1 |t:26| |
Structure |
|