Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 1D

Ligand

BDBM50083096

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1700 (CHEMBL616907)

IC50

2.6±n/a nM

Citation

Russell, MG; Matassa, VG; Pengilley, RR; van Niel, MB; Sohal, B; Watt, AP; Hitzel, L; Beer, MS; Stanton, JA; Broughton, HB; Castro, JL 3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists. J Med Chem42:4981-5001 (2000) [PubMed]

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1D

Name:

5-hydroxytryptamine receptor 1D

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

41920.63

Organism:

Homo sapiens (Human)

Description:

Receptor binding assays were performed using human clone stably expressed in CHO cells.

Residue:

377

Sequence:

MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVL
TTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDIT
CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAK
AQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFT
TAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKAT
KILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFN
EEFRQAFQKIVPFRKAS

BDBM50083096

n/a

Name

BDBM50083096

Synonyms:

CHEMBL357007 | Methyl-(4-methyl-pent-3-enyl)-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-propyl]-piperidin-4-yl}-amine

Type

Small organic molecule

Emp. Form.

C25H36N6

Mol. Mass.

420.5935

SMILES

CN(CCC=C(C)C)C1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1 |(15.54,-6.09,;14.49,-4.94,;14.97,-3.47,;16.48,-3.15,;16.95,-1.68,;18.45,-1.36,;18.91,.1,;19.49,-2.5,;13.01,-5.26,;12.53,-6.73,;11.03,-7.06,;10.01,-5.91,;8.5,-6.25,;8.04,-7.72,;6.54,-8.04,;6.07,-9.51,;6.99,-10.74,;6.09,-12.02,;4.61,-11.54,;3.27,-12.31,;1.93,-11.54,;1.93,-10.01,;3.27,-9.24,;4.59,-10.01,;.61,-9.24,;.45,-7.7,;-1.06,-7.38,;-1.83,-8.72,;-.79,-9.87,;10.45,-4.45,;11.96,-4.13,)|

Structure