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Target5-hydroxytryptamine receptor 1D
LigandBDBM50083096
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1700
IC50 2.6±n/a nM
Citation Russell MGMatassa VGPengilley RRvan Niel MBSohal BWatt APHitzel LBeer MSStanton JABroughton HBCastro JL 3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists. J Med Chem 42:4981-5001 (2000) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 1D
Name:Serotonin (5-HT) receptor
Synonyms:5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | Serotonin Receptor 1D
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41920.63
Organism:Homo sapiens (Human)
Description:Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:377
Sequence:
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVL
TTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDIT
CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAK
AQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFT
TAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKAT
KILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFN
EEFRQAFQKIVPFRKAS
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  Blast E-value cutoff:
BDBM50083096
n/a
NameBDBM50083096
Synonyms:CHEMBL357007 | Methyl-(4-methyl-pent-3-enyl)-{1-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-propyl]-piperidin-4-yl}-amine
TypeSmall organic molecule
Emp. Form.C25H36N6
Mol. Mass.420.5935
SMILESCN(CCC=C(C)C)C1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1 |(15.54,-6.09,;14.49,-4.94,;14.97,-3.47,;16.48,-3.15,;16.95,-1.68,;18.45,-1.36,;18.91,.1,;19.49,-2.5,;13.01,-5.26,;12.53,-6.73,;11.03,-7.06,;10.01,-5.91,;8.5,-6.25,;8.04,-7.72,;6.54,-8.04,;6.07,-9.51,;6.99,-10.74,;6.09,-12.02,;4.61,-11.54,;3.27,-12.31,;1.93,-11.54,;1.93,-10.01,;3.27,-9.24,;4.59,-10.01,;.61,-9.24,;.45,-7.7,;-1.06,-7.38,;-1.83,-8.72,;-.79,-9.87,;10.45,-4.45,;11.96,-4.13,)|
Structure
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