Reaction Details |
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Target | Nociceptin receptor |
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Ligand | BDBM50083231 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_146113 (CHEMBL754582) |
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IC50 | 6.8±n/a nM |
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Citation | Kawamoto, H; Ozaki, S; Itoh, Y; Miyaji, M; Arai, S; Nakashima, H; Kato, T; Ohta, H; Iwasawa, Y Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one (J-113397). J Med Chem42:5061-3 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Nociceptin receptor |
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Name: | Nociceptin receptor |
Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40702.87 |
Organism: | Homo sapiens (Human) |
Description: | P41146 |
Residue: | 370 |
Sequence: | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
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BDBM50083231 |
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n/a |
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Name | BDBM50083231 |
Synonyms: | 1-(1-Cyclooctylmethyl-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one | CHEMBL146191 |
Type | Small organic molecule |
Emp. Form. | C21H31N3O |
Mol. Mass. | 341.4903 |
SMILES | O=c1[nH]c2ccccc2n1C1CCN(CC2CCCCCCC2)CC1 |
Structure |
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