Reaction Details |
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Target | Tryptase beta-2/delta/gamma |
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Ligand | BDBM50217312 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_210823 (CHEMBL811852) |
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Ki | 1100±n/a nM |
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Citation | Ono, S; Kuwahara, S; Takeuchi, M; Sakashita, H; Naito, Y; Kondo, T Syntheses and evaluation of amidinobenzofuran derivatives as tryptase inhibitors. Bioorg Med Chem Lett9:3285-90 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Tryptase beta-2/delta/gamma |
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Name: | Tryptase beta-2/delta/gamma |
Synonyms: | Tryptase |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 1510505 |
Components: | This complex has 3 components. |
Component 1 |
Name: | Tryptase gamma |
Synonyms: | PRSS31 | Serine protease 31 | TMT | TPSG1 | TRYG1_HUMAN | Transmembrane tryptase | Tryptase | Tryptase gamma | Tryptase gamma heavy chain | Tryptase gamma light chain |
Type: | PROTEIN |
Mol. Mass.: | 33817.52 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_210833 |
Residue: | 321 |
Sequence: | MALGACGLLLLLAVPGVSLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRM
HVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFSTVRQIILHSSPSGQP
GTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLR
EVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDACQDDSGGPLVCQVNGAWVQAGTV
SWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSESGYPRLPLLAGLFLPGLFLLLVSC
VLLAKCLLHPSADGTPFPAPD
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Component 2 |
Name: | Tryptase beta-2 |
Synonyms: | TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2 |
Type: | PROTEIN |
Mol. Mass.: | 30518.79 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_210702 |
Residue: | 275 |
Sequence: | MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCG
GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA
DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKV
PIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAG
VVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
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Component 3 |
Name: | Tryptase delta |
Synonyms: | Delta-tryptase | HmMCP-3-like tryptase III | Mast cell mMCP-7-like | TPSD1 | TRYD_HUMAN | Tryptase delta | Tryptase-3 |
Type: | PROTEIN |
Mol. Mass.: | 26578.73 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_104777 |
Residue: | 242 |
Sequence: | MLLLAPQMLSLLLLALPVLASPAYVAPAPGQALQQTGIVGGQEAPRSKWPWQVSLRVRGP
YWMHFCGGSLIHPQWVLTAAHCVEPDIKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQF
YIIQTGADIALLELEEPVNISSHIHTVTLPPASETFPPGMPCWVTGWGDVDNNVHLPPPY
PLKEVEVPVVENHLCNAEYHTGLHTGHSFQIVRDDMLCAGSENHDSCQGDSGGPLVCKVN
GT
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BDBM50217312 |
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n/a |
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Name | BDBM50217312 |
Synonyms: | CHEMBL324918 |
Type | Small organic molecule |
Emp. Form. | C52H50N8O8 |
Mol. Mass. | 915.0022 |
SMILES | N=C(NCc1ccccc1)c1ccc2oc(cc2c1)C(=O)N1CCN(CC1)C(=O)COc1ccc(OCC(=O)N2CCN(CC2)C(=O)c2cc3cc(ccc3o2)C(=N)NCc2ccccc2)cc1 |
Structure |
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