Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucocorticoid receptor | ||
| Ligand | BDBM50083757 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_71413 (CHEMBL685131) | ||
| IC50 | 3.4±n/a nM | ||
| Citation |  Biggadike, K; Angell, RM; Burgess, CM; Farrell, RM; Hancock, AP; Harker, AJ; Irving, WR; Ioannou, C; Procopiou, PA; Shaw, RE; Solanke, YE; Singh, OM; Snowden, MA; Stubbs, RJ; Walton, S; Weston, HE Selective plasma hydrolysis of glucocorticoid gamma-lactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism. J Med Chem43:19-21 (2000) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucocorticoid receptor | |||
| Name: | Glucocorticoid receptor | ||
| Synonyms: | GCR_HUMAN | GR | GRL | Glucocorticoid | Glucocorticoid receptor (GRFP) | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85656.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P04150 | ||
| Residue: | 777 | ||
| Sequence: |
| ||
| BDBM50083757 | |||
| n/a | |||
| Name | BDBM50083757 | ||
| Synonyms: | CHEMBL302366 | Isomer of 4b,12-Difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-6b-[2-(2-oxo-tetrahydro-furan-3-ylsulfanyl)-acetyl]-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-2-one | Isomer of4b,12-Difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-6b-[2-(2-oxo-tetrahydro-furan-3-ylsulfanyl)-acetyl]-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-2-one | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H34F2O7S | ||
| Mol. Mass. | 552.627 | ||
| SMILES | CC1(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CSC1CCOC1=O |c:15,t:11| | ||
| Structure | 
| ||