| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine 3-monooxygenase |
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| Ligand | BDBM50083950 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_91745 (CHEMBL700046) |
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| IC50 | 4000±n/a nM |
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| Citation |  Drysdale, MJ; Hind, SL; Jansen, M; Reinhard, JF Synthesis and SAR of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids and esters and 2-amino-4-aryl-4-oxobut-2-enoic acids and esters: potent inhibitors of kynurenine-3-hydroxylase as potential neuroprotective agents. J Med Chem43:123-7 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine 3-monooxygenase |
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| Name: | Kynurenine 3-monooxygenase |
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| Synonyms: | KMO_RAT | Kmo |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54371.88 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1487468 |
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| Residue: | 478 |
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| Sequence: | MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSY
RGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLT
AVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKK
PRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMS
FEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCV
LMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLS
MYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKK
VINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH
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| BDBM50083950 |
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| n/a |
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| Name | BDBM50083950 |
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| Synonyms: | (S)-(+)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid[(S)-(+)-m-nicotinylbenzoylalanine] | (S)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid | CHEMBL22740 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H10N2O5 |
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| Mol. Mass. | 238.1968 |
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| SMILES | N[C@@H](CC(=O)c1cccc(c1)[N+]([O-])=O)C(O)=O |
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| Structure | 
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