| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50085707 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_71750 (CHEMBL680272) |
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| Ki | 0.74±n/a nM |
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| Citation |  Rivier, JE; Struthers, RS; Porter, J; Lahrichi, SL; Jiang, G; Cervini, LA; Ibea, M; Kirby, DA; Koerber, SC; Rivier, CL Design of potent dicyclic (4-10/5-8) gonadotropin releasing hormone (GnRH) antagonists. J Med Chem43:784-96 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37767.60 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1335047 |
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| Residue: | 327 |
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| Sequence: | MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50085707 |
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| n/a |
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| Name | BDBM50085707 |
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| Synonyms: | CHEMBL411197 | Cyclo (4-10) [Ac-Delta Pro, D Fpa, D Trp, Asp, MeTyr, D Nal, Leu, Lys, Pro, Dpr]GnRH |
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| Type | Small organic molecule |
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| Emp. Form. | C64H85FN14O13 |
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| Mol. Mass. | 1277.4441 |
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| SMILES | CC(C)C[C@H]1NC(=O)[C@H](C)NC(=O)[C@@](C)(Cc2ccc(O)cc2)NC(=O)[C@@H](CC(=O)NCC(NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC1=O)C(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1CCCN1C(C)=O |
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| Structure | 
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